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2004
Fused pyridine derivatives
R 0450
Rational Design, Synthesis and Biological Evaluation of 3H-Naphtho[1,2,3-de]A New Class of Potential Antitumor Agents. — A variety
51- 116 -quinoline-2,7-diones:
of the novel title compounds (III) (10 examples) are synthesized by nucleophilic substitution of the commercially available 6-bromonaphthoquinolinedione (I) with alkylamines and evaluated for their cytotoxicity on different cell lines. Compound (IIIc),
which shows good cytotoxicity and low or none cross resistance with Cs on resistant
cell lines, can be regarded as a new lead for the development of intercalating anticancer
agents. — (ANTONINI*, I.; POLUCCI, P.; MAGNANO, A.; SPARAPANI, S.;
MARTINELLI, S.; Pol. J. Chem. 78 (2004) 8, 1019-1025; Dip. Sci. Chim., Univ.
Camerino, I-62032 Camerino, Macerata, Italy; Eng.) — M. Schroeter
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