close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2004
Purine derivatives
R 0540
New N6-Substituted 8-Alkyl-2-phenylmethylsulfanyl-Adenines. Part 2. — Title
compounds (IX) and (X) are synthesized in view of their potential as ligands at P2Y
51- 133 purinoreceptors.
Starting from two thiobarbituric acid derivatives the synthesis of
2-thioalkylpurines is attempted. The construction of a purine ring via introduction of a
functional group at C-5 of the pyrimidine core through electrophilic substitution fails.
However, the second approach to functionalization at C-5 proceeds successfully by
using the route from aminothiobarbituric acid (I) to the newly synthesized pyrimidine
derivative (V). Annulation of (V) forms the hypoxanthines (VII) which, in turn are converted to amino derivatives (IX) by successive use of phosphorus oxychloride and alkylamines (VIII). Sulfonyl derivatives (X) and (XI) are also prepared. — (BIAGI, G.;
GIORGI*, I.; LIVI, O.; PACCHINI, F.; SCARTONI, V.; SALERNI, O. L.; J.
Heterocycl. Chem. 41 (2004) 4, 581-585; Dip. Sci. Farm., Univ. Pisa, I-56126 Pisa,
Italy; Eng.) — H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
28 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа