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2004
Pyrimidine derivatives
R 0510
A Facile One-Pot Synthesis of Novel Substituted 1,2,3,4-Tetrahydropyrimidine.
2. Synthesis of 1-(Aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tet52- 134 Part
rahydropyrimidines. — The synthesis of aroyltetrahydropyrimidines (IVa)—(IVc) is
achieved by dethiomethylation of methylthiotetrahydropyrimidines (V), synthesized
by a facile one-pot procedure. In order to achieve the synthesis of the title compounds
in a single step, an alternative strategy using enaminones (I) as starting material is
employed. The reaction of compounds of type (I) with formaldehyde (II), alkyl, arylalkyl, and aryl amines such as (III) is found to be general and furnishes the stable title
compounds (IV) in a range from 35 to 83% yield. — (CHANDA, K.; DUTTA, M. C.;
KARIM, E.; VISHWAKARMA*, J. N.; J. Heterocycl. Chem. 41 (2004) 4, 627-631;
Dep. Chem., St. Anthony's Coll., Shillong 793 001, India; Eng.) — H. Hoennerscheid
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