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2005
Imidazole derivatives
R 0190
Ring-Substituted Imidazoles as a New Class of anti-Tuberculosis Agents. —
series of ring-substituted imidazoles [cf. derivatives (III), (IV), (V), (VII), (VIII), and
01- 103 A
(X)] is prepared and evaluated as possible anti-tuberculosis agents. Compound (IVb)
and its dicyclopentyl-substituted analogue show 91-99% inhibition at 6.25 µg/ml
against Mycobacterium tuberculosis H37Rv strain. — (GUPTA, P.; HAMEED, S.;
JAIN*, R.; Eur. J. Med. Chem. 39 (2004) 9, 805-814; Dep. Med. Chem., Natl. Inst.
Pharm. Educ. Res., Punjab 160 062, India; Eng.) — R. Staver
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