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2005
Fused pyridine derivatives
R 0450
Bisbenzothieno[3,2-b:2',3'-e]pyridine. — Attempts to obtain benzothienopyridone
starting material in the synthesis of antimalarial drugs, by reaction of the benzo01- 130 (III),
thiophenecarboxylate (I) with ethyl propiolate (II) affords the dihydrobisbenzothienopyridinyl acetate (IV) as main product along with minor amounts of desired pyridone (III). The dehydrogenation of the ester (IV) leads to bisbenzothienopyridine (V)
in high yield, which suffers unexpected decarboxylation during alkaline saponification.
— (GOERLITZER*, K.; MEYER, H.; Pharmazie 59 (2004) 9, 673-675; Inst. Pharm.
Chem., TU Braunschweig, D-38106 Braunschweig, Germany; Ger., Abstr. Eng.) —
R. Staver
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