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2005
Other bioactive products
U 1300
An Efficient Total Synthesis of Optically Active Tetrodotoxin. — The total syntheof optically active tetrodotoxin which is a toxic principle of puffer-fish poison and
01- 200 sis
acts as a specific blocker of voltage-dependent sodium channels is described. The same
procedure can be applied to prepare a variety of tetrotoxin derivatives which cannot be
obtained from natural products. — (NISHIKAWA, T.; URABE, D.; ISOBE*, M.;
Angew. Chem., Int. Ed. 43 (2004) 36, 4782-4785; Grad. Sch. Bioagric. Sci., Nagoya
Univ., Chikusa, Nagoya 464, Japan; Eng.) — S. Adam
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