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2005
Indole derivatives
R 0140
N-Benzyl-2-chloroindole-3-carboxylic Acids as Potential Antiinflammatory
Agents. Synthesis and Screening for the Effects on Human Neutrophil Functions
02- 103 and
on COX1/COX2 Activity. — A series of the title 2-chloroindolecarboxylic acids
related to indomethacin [cf. (IV), (V), (VII)] are synthesized and evaluated for their
inhibitory activity on human neutrophil functions and for their COX1/COX2 inhibitory
activity. Some derivatives, e.g. (V), are more active than the parent compound. —
(ANDREANI*, A.; GRANAIOLA, M.; LEONI, A.; LOCATELLI, A.; MORIGI, R.;
RAMBALDI, M.; RODA, A.; GUARDIGLI, M.; TRANIELLO, S.; SPISANI, S.;
Eur. J. Med. Chem. 39 (2004) 9, 785-791; Dip. Sci. Farm., Univ. Bologna, I-40126
Bologna, Italy; Eng.) — R. Staver
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