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2005
Triazole derivatives
R 0280
Synthesis and Antimicrobial Activities of Some New 1-(5-Phenylamino-[1,3,4]thiadiazol-2-yl)methyl-5-oxo-[1,2,4]triazole and 1-(4-Phenyl-5-thioxo-[1,2,4]triaz02- 118 ol-3-yl)methyl-5-oxo-[1,2,4]triazole
Derivatives. — With the aim to find novel antimicrobial and anticancer agents, a variety of 5-oxo-[1,2,4]triazoles [cf. compounds
(IV), (VI), (VII), and (VIII)] is synthesized and evaluated. Derivatives (IVa-c), (VII),
and (VIIIa,c) possess antimicrobial activity, while compound (IVd) is active against the
MCF7 breast cancer cell lines. — (DEMIRBAS*, N.; KARAOGLU, S. A.;
DEMIRBAS, A.; SANCAK, K.; Eur. J. Med. Chem. 39 (2004) 9, 793-804; Dep.
Chem., Karadeniz Tech. Univ., TR-61080 Trabzon, Turk.; Eng.) — R. Staver
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