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2005
Pyridine derivatives
R 0380
Synthesis and Calcium Channel Antagonist Activity of New 1,4-Dihydropyridine
Derivatives Containing Lipophilic 4-Imidazolyl Substituents. — A variety of
02- 134 cycloalkyl
and aryl ester analogues of nifedipine, compounds (III) and (VI), are synthesized via classical or modified Hantzsch methodology, resp., and evaluated as calcium channel antagonists. Some compounds, e.g. (IIIa) and (Va), possess similar activity to, and derivatives such as compounds (IIIb), (IIIc) and (IIIe) show even higher
activity than the reference drug nifedipine. — (NAVIDPOUR, L.; MIRI, R.;
SHAFIEE*, A.; Arzneim.-Forsch. 54 (2004) 9, 499-504; Dep. Med. Chem., Fac.
Pharm., Tehran Univ. Med. Sci., Tehran, Iran; Eng.) — H. Toeppel
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