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2005
Pyrimidine derivatives
R 0510
Synthesis of Certain 6-(Arylthio)uracils and Related Derivatives as Potential
Agents. — New series of 6-(arylthio)uracils (V) and related derivatives such
02- 154 Antiviral
as piperazinylpyrazines (IX) and tricyclic pyrimidine derivatives (VII), (XIII) are synthesized and evaluated for their in vitro antiviral activity as well as cytotoxicity. Arylthiouracils (Vb) and (Vd) exhibit marginal activity against HIV-1. Moreover, compound (Vb) exhibits marginal activity against HSV-1. — (EL-EMAM*, A. A.;
MASSOUD, M. A. M.; EL-BENDARY, E. R.; EL-SAYED, M. A.; Bull. Korean
Chem. Soc. 25 (2004) 7, 991-996; Dep. Pharm. Chem., Coll. Pharm., King Saud Univ.,
Riyadh 11451, Saudi Arabia; Eng.) — C. Hettrich
2005
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