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2005
Fused pyrimidine derivatives
R 0515
One Pot Synthesis of Thiazolodihydropyrimidinones and Evaluation of Their
Anticancer Activity. — A variety of thiazolodihydropyrimidinones (VI) and (VIII) are
02- 156 synthesized
by a novel three-component reaction of thiones (III), chloroacetic acid (V),
and furfural derivatives (IV) or (VII), respectively. The prepared compounds (III), (VI),
and (VIII) show moderate to excellent in vitro anticancer activity. — (HOLLA*, B.
S.; RAO, B. S.; SAROJINI, B. K.; AKBERALI, P. M.; Eur. J. Med. Chem. 39 (2004)
9, 777-783; Dep. Postgrad. Stud. Res. Chem., Mangalore Univ., Mangalagangothri,
Mangalore 574 199, India; Eng.) — R. Staver
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