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2005
Nucleic acids
U 0700
Facile and Efficient Synthesis of 6-(Hydroxymethyl)purines. — The title approach
based on Pd-catalyzed cross-coupling reactions of 6-halopurines with zinc com02- 214 ispounds
(II) followed by deprotection. Derivative (IIb) appears to be the most practical
reagent because the benzoyl group is sufficiently stable during the metalation and
cross-coupling but can be easily cleaved off. Various products are subjected to biological activity screening. Cytostatic and adenosine deaminase inhibitory effects are
observed with (XIIIb) being the most active one. — (SILHAR, P.; POHL, R.;
VOTRUBA, I.; HOCEK*, M.; Org. Lett. 6 (2004) 19, 3225-3228; Inst. Org. Chem.
Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) —
Steudel
2005
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