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2005
Antibiotics
U 1200
02- 221
Cephalosporins with the Dichlorophenyl Group at C-7 Position and Pyrimidines
at C-3 Position Exhibiting Potent Activity Against Gram-Positive Strains. — A
series of title compounds with different spacer groups connecting the pyrimidine group
are prepared and tested for their antibacterial activities. Compounds such as (Ia)—(Ic)
show balanced antibacterial activities. Especially (Ic) displays an excellent pharmacokinetic profile when administered in rats with 20 mg/kg. — (KIM*, G. T.; RYU, E.-J.;
JANG, Y.-J.; LEE, C.-S.; YOUN, H.; CHO, Y. R.; JOO, H. Y.; J. Antibiot. 57 (2004)
7, 468-472; Life Sci. R & D, LG Chem. Ltd., Taejon 305-380, S. Korea; Eng.) —
M. Bohle
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