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2005
Other bioactive products
U 1300
FR182876, a New Microtubule Modulator with High Water-Solubility, from a
— FR182876 (I) is isolated from a Streptomyces strain which also pro02- 224 Streptomyces.
duces FR182877. As spectroscopic methods could not solve the structure of (I), chemical correlations are combined with spectroscopic methods. (I) has a highly fused ring
system and a 3-methylhistidine moiety which is believed to contribute to the water-solubility. (I) shows potent cytotoxicity against a panel of cancer cells. —
(YOSHIMURA*, S.; SATO, B.; TAKASE, S.; TERANO, H.; J. Antibiot. 57 (2004) 7,
429-435; Explor. Res. Lab., Fujisawa Pharm. Co., Ltd., Tsukuba, Ibaraki 300-26,
Japan; Eng.) — M. Bohle
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