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2005
Ketones
P 0200
03- 079
Tandem Enantioselective Organo- and Biocatalysis: A Direct Entry for the Synthesis of Enantiomerically Pure Aldols. — Direct proline-catalyzed aldol reactions
are linked in sequence with lipase-catalyzed kinetic resolution to afford enantiomerically pure aldol adducts in higher conversion than a standard resolution of racemic materials. Interestingly, the combination of organocatalytic aldol reaction and enzymatic
kinetic resolution provides exclusively either the (R)- or (S)-enantiomer of the aldol
adduct even though the enzyme only exists in one enantiomeric form. Furthermore, this
transformation sequence can be performed as an one-pot tandem reaction. — (EDIN,
M.; BAECKVALL*, J.-E.; CORDOVA, A.; Tetrahedron Lett. 45 (2004) 41,
7697-7701; Dep. Org. Chem., Arrhenius Lab., Univ. Stockholm, S-106 91 Stockholm,
Swed.; Eng.) — M. Paetzel
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