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2005
Triazine derivatives
R 0655
Pyridazine Derivatives and Related Compounds. Part 13. Synthesis and AntimiActivity of Some Pyridazino[3',4':3,4]pyrazolo[5,1-c]-1,2,4-triazines. —
03- 157 crobial
Pyrazolopyridazine and pyrazolotriazine ring systems are combined to a molecular
framework to examine the additive effect of these rings toward the biocidal activities.
Pyrazolopyridazine (I) is prepared according to a literature method. Its reaction with
different β-bifunctional reagents is the appropriate method to furnish the title compounds. The in vitro antimicrobial activity of 27 compounds is screened. Among these
compounds, e.g. (VI), (VIIIa) and (X), eight show antibacterial activity. — (DEEB*,
A.; EL-MARIAH, F.; HOSNY, M.; Bioorg. Med. Chem. Lett. 14 (2004) 19,
5013-5017; Dep. Chem., Fac. Sci., Zagazig Univ., Zagazig, Egypt; Eng.) —
H. Hoennerscheid
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