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2005
Lipids
U 0750
03- 202
Synthesis and Biological Evaluation of Novel Cytotoxic Phospholipids for Prostate
Cancer. — Serine amide alcohols and phosphates like (IV), (V), and (VI), derivatives
of the natural glycerophospholipid lysophosphatidic acid, represent a new class of cytotoxic phospholipids for prostate cancer. The cytotoxicity is examined in five human
prostate cancer cell lines as well as in two negative control cell lines. Compounds (IV),
(V), and (VI) are potent inhibitors of prostate tumor cell proliferation at low micromolar
cytotoxicity, but they are not selective against nontumor CHO cells and receptor-negative RH777 cells. The chirality of the derivatives is not important for antiproliferative
activity. — (GUDUDURU, V.; HURH, E.; DURGAM, G. G.; HONG, S. S.; SARDAR,
V. M.; XU, H.; DALTON, J. T.; MILLER*, D. D.; Bioorg. Med. Chem. Lett. 14
(2004) 19, 4919-4923; Dep. Pharm. Sci., Coll. Pharm., Univ. Tenn., Memphis,
TN 38163, USA; Eng.) — H. Hoennerscheid
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