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2005
Thiadiazole derivatives
R 0300
Improved Synthesis, Antibacterial Activity and Potential Carcinogenicity of
— Improved procedures for the synthesis of
04- 136 5-Amino-1,2,4-thiadiazol-3(2H)-one.
thiobiuret (II), some of its methyl derivatives [cf. (VI), (X), (XII)] and the title thiadiazole (III) are described. Moreover, studies on the reductive cleavage, the alkaline
degradation course and the antibacterial activity of thiadiazole (III) as well as the potential carcinogenicity of all the compounds prepared are given. — (PISKALA, A.;
VACHALKOVA, A.; MASOJIDKOVA, M.; HORVATHOVA, K.; OVESNA, Z.;
PACES, V.; NOVOTNY*, L.; Pharmazie 59 (2004) 10, 756-762; Fac. Pharm., Kuwait
Univ., 13110 Safat, Kuwait; Eng.) — M. Bohle
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