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2005
Benzopyran derivatives
R 0350
Benzopyranones with Retro-Amide Side Chains as (Inhibitory) β-Lactamase Sub— 3-Carbamoylbenzopyranones (I) are synthesized (no yields are given) and
04- 142 strates.
found to be comparably effective as substrates of typical class A, C and D β-lactamases
as analogous benzopyranones bearing 'normal' amide side chains. The new 8-carboxy
derivative (Ib), however, forms a much more tightly-bound acyl-enzyme with a class
C β-lactamase compared to its 'normal' analogue, and thus provides a structural lead to
new inhibitors of this class of β-lactamase. — (ADEDIRAN, S. A.; CABARET, D.;
LOHIER, J.-F.; WAKSELMAN, M.; PRATT*, R. F.; Bioorg. Med. Chem. Lett. 14
(2004) 20, 5117-5120; Dep. Chem., Wesleyan Univ., Middletown, CT 06459, USA;
Eng.) — M. Schroeter
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