close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Multi-membered N-heterocycles
R 0690
Application of the Stille Coupling Reaction to the Synthesis of C2-Substituted
Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs). — Five novel
04- 177 endo—exo
title pyrrolobenzodiazepines (IV) and (VI) are synthesized using Stille coupling reaction of key enol triflate (I). All these novel compounds possess potent cytotoxicity.
Structure-activity relationship studies indicate the importance of planar C2-substituents
in potentiating biological activity. — (TIBERGHIEN, A. C.; HAGAN, D.;
HOWARD*, P. W.; THURSTON*, D. E.; Bioorg. Med. Chem. Lett. 14 (2004) 20,
5041-5044; Cancer Res. UK, Gene Targeted Drug Des. Res. Group, Sch. Pharm., Univ.
London, London WC1N 1AX, UK; Eng.) — M. Schroeter
Документ
Категория
Без категории
Просмотров
0
Размер файла
22 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа