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2005
Amino acids
U 0400
Synthesis and Cytotoxic Activity of Novel Derivatives of 4'-Demethylepipodophyl— The preparation of the novel title compounds (VI) (9 examples) by com04- 197 lotoxin.
bining a 4'-demethylepipodophyllotoxin moiety with a natural L-amino acid and their
evaluation as potential antitumor agents are described. Preliminary results show that
these compounds show more effective cytotoxic activity than both the clinically used
parent drugs VP-16 and 5-FU. Compound (VIIIc) is identified as the most potent cytotoxic agent in this series. — (CHEN, S.-W.; TIAN*, X.; TU*, Y.-Q.; Bioorg. Med.
Chem. Lett. 14 (2004) 20, 5063-5066; State Key Lab. Appl. Org. Chem., Inst. Org.
Chem., Lanzhou Univ., Lanzhou 730000, Gansu, Peop. Rep. China; Eng.) —
M. Schroeter
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