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2005
Other bioactive products
U 1300
An Easy Three Step Synthesis of Perfluoroalkylated Amphetamines. — A general
of perfluoroalkylated amphetamines (VI) and (VII) is described. Initially,
04- 213 synthesis
1-iodo-(perfluoroalkyl)ethylenes (III) are prepared by radical addition of iodides (II) to
acetylenes (I). Key step of the reaction sequence is the following dehydroiodination in
the presence of BuLi to give (perfluoroalkyl)acetylenes in situ, which are reacted with
secondary amines (IV) to produce enamines (V) in a one-pot procedure. Finally, hydrogenation affords the target products in high yields. — (TEWARI, A.; HEIN*, M.;
ZAPF, A.; BELLER, M.; Tetrahedron Lett. 45 (2004) 41, 7703-7707; Fachber.
Chem., Univ. Rostock, D-18055 Rostock, Germany; Eng.) — M. Paetzel
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