close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Amines
Q 0120
05- 071
CuBr-Catalyzed Efficient Alkynylation of sp3 C—H Bonds Adjacent to a Nitrogen
Atom. — A simple and effective method to form propargylamines involves the
CuBr-catalyzed reaction of aromatic or aliphatic terminal alkynes with amines (I) and
(VI), tetrahydroisoquinoline (VIII) and piperidine (X) in the presence of stoichiometric
amounts of tBuOOH. Functional groups such as alcohol and ester are tolerated. In the
case of benzyldimethylamine (VI), the alkynylation takes place preferentially at the
alkyl rather than the benzyl position. Interestingly, piperidine (X) gives, besides the
desired alkynylation product (XII), compound (XIII) derived from alkynylation and
tert-butoxylation. — (LI, Z.; LI*, C.-J.; J. Am. Chem. Soc. 126 (2004) 38,
11810-11811; Dep. Chem., McGill Univ., Montreal, Que. H3A 2K6, Can.; Eng.) —
Klein
Документ
Категория
Без категории
Просмотров
0
Размер файла
27 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа