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2005
Pyridine derivatives
R 0380
New Entries in Lewis Acid—Lewis Base Bifunctional Asymmetric Catalyst:
Enantioselective Reissert Reaction of Pyridine Derivatives. — Two bi05- 125 Catalytic
functional catalysts derived from chiral binaphthols (I) or (II) and Et2AlCl are successfully employed in the reaction of nicotinic acid derivatives with TmsCN and chloroformates. The resulting Reissert products are obtained in high yields and enantioselectivities. The synthetic utility of these chiral building blocks is demonstrated by synthesis
of compound (VII), a known intermediate of the route to dopamine antagonist
CP-293,019. — (ICHIKAWA, E.; SUZUKI, M.; YABU, K.; ALBERT, M.; KANAI,
M.; SHIBASAKI*, M.; J. Am. Chem. Soc. 126 (2004) 38, 11808-11809; Grad. Sch.
Pharm. Sci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan; Eng.) — Klein
2005
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