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2005
Multi-membered N-heterocycles
R 0690
Synthesis and in vitro Evaluation of New Azaphenylalanine Derivatives as Serine
Inhibitors. — A variety of new azaphenylalanine derivatives such as (IV),
05- 148 Protease
(V) or (IX) is prepared and tested as serine protease inhibitors. (IX) shows submicromolar inhibitory constants against both thrombin and factor Xa and is selected as lead
compound for further studies. — (OBREZA, A.; STEGNAR, M.;
TRAMPUS-BAKIJA, A.; PREZELJ, A.; URLEB*, U.; Pharmazie 59 (2004) 10,
739-743; Fac. Pharm., Univ. Ljubljana, 1000 Ljubljana, Slovenia; Eng.) — M. Bohle
2005
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