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2005
Amino acids
U 0400
N-Sulfonyl Homoserine Lactones as Antagonists of Bacterial Quorum Sensing.
The synthesis of new analogues of N-acylhomoserine lactones such as (V) and (VI)
05- 177 —
(11 examples in all) in which the carboxamide function is replaced by a sulfonamide,
and their evaluation as antagonists of bacterial quorum sensing are described. Several
compounds, especially compounds (Va) and (Vc), display antagonistic activity. —
(CASTANG, S.; CHANTEGREL, B.; DESHAYES, C.; DOLMAZON, R.; GOUET, P.;
HASER, R.; REVERCHON, S.; NASSER, W.; HUGOUVIEUX-COTTE-PATTAT, N.;
DOUTHEAU*, A.; Bioorg. Med. Chem. Lett. 14 (2004) 20, 5145-5149; Lab. Chim.
Org., Dep. Biochim., Inst. Natl. Sci. Appl., F-69621 Villeurbanne, Fr.; Eng.) —
M. Schroeter
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