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2005
Pyridine derivatives
R 0380
Synthesis and Deprotonation of 2-(Halophenyl)pyridines and 1-(Halophenyl)iso— Deprotonation of the title compounds takes place at the phenyl ring. The
06- 137 quinolines.
azine ring is not attacked. Bromo and chloro substituted rings are deprotonated at the
2' position, whereas the reaction of fluoro derivatives occurs next to the fluoro group.
This indicates that the fluoro unit is a stronger directing group than 2-pyridyl and 1-isoquinolyl moieties. Interestingly, starting from dihalides of type (V) iodine migration
takes place. — (MONGIN*, F.; REBSTOCK, A.-S.; TRECOURT, F.; QUEGUINER,
G.; MARSAIS, F.; J. Org. Chem. 69 (2004) 20, 6766-6771; Lab. Chim. Org. Fine
Heterocycl., IRCOF, Inst. Natl. Sci. Appl. Rouen, F-76131 Mont-Saint-Aignan, Fr.;
Eng.) — Jannicke
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