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2005
Other bioactive products
U 1300
Synthesis of 1-Glycosyl Derivatives of Benzocamalexin. — Four glycosylbenzocaderived from D-glucose, D-galactose, D-mannose, and D-ribose are synthe06- 216 malexins
sized using a linear approach, the indoline-indole method. This method has the advantage of enhanced nucleophilicity of indoline in comparison with the less nucleophilic
indole ring. The high reactivity of indoline (II) facilitates its reaction with either unprotected saccharides or their peracetylated derivatives like mannose (I). Vilsmeier formylation of indoles (IV) or (V) yields the corresponding indolecarbaldehydes as key
intermediates, suitable for further functional manipulations. Compound (X) and its
ribose analogue are active in a primary in vitro screening test for their anticancer effect.
— (HUMENIK*, M.; DZURILLA, M.; KUTSCHY, P.; SOLCANIOVA, E.;
KOVACIK, V.; BEKESOVA, S.; Collect. Czech. Chem. Commun. 69 (2004) 8,
1657-1674; Inst. Chem. Sci., Fac. Sci., Safarik Univ., SK-041 67 Kosice, Slovakia;
Eng.) — H. Hoennerscheid
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