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2005
Fused pyrrole derivatives
R 0160
Diastereoselective Syntheses of New Analogues of the Farnesyltransferase InhibRPR 130401. — The synthesis of the title analogues (IX) and (X) is achieved via
07- 105 itor
stereoselective cycloaddition of the pyrroline (III) to the benzofuran (IV). Depending
on the conditions, the syn- or the anti-adduct can be formed predominantly. Additionally, it is shown that the nature of the N-substituent also affects the stereoselectivity.
Unfortunately, (IX) and (X) do not exhibit any farnesyltransferase inhibitory activity.
— (PICHON, N.; MARRISON-MARCHAND, A.; MAILLIET, P.; MADDALUNO*,
J.; J. Org. Chem. 69 (2004) 21, 7220-7227; Lab. Fonct. Azotees Oxygenees
Complexes, Inst. Rech. Chim. Org. Fine, Univ. Rouen, F-76821 Mont-Saint-Aignan,
Fr.; Eng.) — Jannicke
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