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2005
Indole derivatives
R 0140
Synthesis, Spectroscopic Studies and Crystal Structure of
as the Inhibitor of Cell Proliferation
08- 113 5,5'-Dimethoxy-3,3'-methanediyl-bis-indole
of Human Tumors. — Since usual reductive cyclization procedures of 2-nitrostyrene
derivatives are not very effective for the preparation of methoxyindoles, the reductive
cyclization procedure for the synthesis of diindolylmethane (VII), is carried out by
employing trimorpholylmethane (III) in the first step. The molecular structure of diindolylmethane (VII) is analyzed by single X-ray diffraction. NH-π Interactions are
observed as for other indoles and for globular proteins, and possibly play a functional
role in biological features of (VII). Diindolylmethane (VII) reduces the growth of
MCF7 and NCS cells. — (MACIEJEWSKA, D.; NIEMYJSKA, M.; WOLSKA, I.;
WLOSTOWSKI, M.; RASZTAWICKA, M.; Z. Naturforsch., B: Chem. Sci. 59 (2004)
10, 1137-1142; Chair Lab. Org. Chem., Fac. Pharm., Med. Acad.,
PL-02-097 Warszawa, Pol.; Eng.) — H. Hoennerscheid
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