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2005
Fused pyridine derivatives
R 0450
Synthesis and Reactions of Some New Heterocyclic Compounds Containing the
Moiety. — Propenone derivatives (I) are condensed
08- 152 Thienylthieno[2,3-b]pyridine
with cyanothioacetamide (II) to assemble the basic skeleton (III) which is used as starting material for the synthesis of the title compounds via three key intermediates, e.g.
(VI). The synthesis of the thienopyridines includes the preparation of cyanopyridinethiones, imidazolothienopyridines, pyranothienopyridines, pyrazolinothienopyridines,
pyridothienopyrimidines, and thienopyridines, which might exhibit enhanced activities
owing to the incorporation of different pharmacophores into their skeletons. —
(BAKHITE*, E. A.; ABDEL-RAHMAN, A. E.; MOHAMED, O. S.; THABET, E. A.;
Phosphorus, Sulfur Silicon Relat. Elem. 179 (2004) 10, 1983-2006; Dep. Chem., Fac.
Sci., Assiut Univ., Assiut 71516, Egypt; Eng.) — H. Hoennerscheid
2005
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