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2005
Imidazole derivatives
R 0190
Design and Synthesis of 1-(4-Benzoylphenyl)imidazole Derivatives as New Potent
Synthase Inhibitors. — Starting with a recently found substance several
09- 108 20-HETE
kinds of novel derivatives such as (VII) are prepared. The most active inhibitor of the
title enzyme is (VIIb) with an IC50 value of 7.9 nM. A modeling study with a predicted
crystal structure of arachidonic acid and the crystal structure of (VIIc) are presented.
— (NAKAMURA*, T.; ISHII, T.; MIYATA, N.; TANIGUCHI, K.; TOMISHIMA, Y.;
UEKI, T.; SATO*, M.; Bioorg. Med. Chem. Lett. 14 (2004) 21, 5305-5308; Med.
Res. Lab., Taisho Pharm. Co. Ltd., Omiya, Saitama 330, Japan; Eng.) —
K. Schneider
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