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2005
Multi-membered N-heterocycles
R 0690
Evaluation of Alternative Approaches for the Synthesis of Macrocyclic Bisindolyl— Two approaches towards the title compounds are investigated: the first
09- 171 maleimides.
is based on macrocyclization in the northern region, the second on cyclization in the
southern region. Successful preparation of macrocycles is achieved using the second
approach, provided that the length of the tether formed between the indole moieties is
at least six atoms. — (BARTLETT, S.; NELSON*, A.; Org. Biomol. Chem. 2 (2004)
19, 2874-2883; Sch. Chem., Univ. Leeds, Leeds LS2 9JT, UK; Eng.) — Nuesgen
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