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2005
Enzyme inhibiting activity
X 0220
Design, Synthesis, and Activity of 4-Quinolone and Pyridone Compounds as NonFarnesyltransferase Inhibitors. — Starting with tipifarnib a novel
09- 245 thiol-Containing
set of compounds such as (I) are designed and synthesized. The 4-quinolone structure
(Ib) as a potent inhibitor may be the basis for an extended study in this structural class.
— (LI*, Q.; et al.; Bioorg. Med. Chem. Lett. 14 (2004) 21, 5367-5370; Cancer Res.,
Abbott Lab., Abbott Park, IL 60064, USA; Eng.) — K. Schneider
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