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2005
Enzyme inhibiting activity
X 0220
Synthesis and Activity of 1-Aryl-1'-imidazolyl Methyl Ethers as Non-Thiol FarneInhibitors. — In order to get more insight into the structure activity re10- 244 syltransferase
lationships of the title compounds substances such as (I) are synthesized. (Id) shows
potent in vitro enzymatic activity with IC50 values in the subnanomolar range while
maintaining cellular activity comparable to tipifarnib. — (LI*, Q.; et al.; Bioorg.
Med. Chem. Lett. 14 (2004) 21, 5371-5376; Cancer Res., Abbott Lab., Abbott Park,
IL 60064, USA; Eng.) — K. Schneider
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