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2005
Biochemical syntheses
O 0035
Rapid Identification of New Bacterial Alcohol Dehydrogenases for (R)- and
Reduction of β-Ketoesters. — New bacterial alcohol dehydro11- 051 (S)-Enantioselective
genases with high and complementary enantioselectivity for the reduction of
β-ketoesters (I) and (III) are identified by use of a new methodology consisting of preselection of microorganisms based on degradation ability and high-throughput screening with a miniaturized system coupled with fast analysis of enantioselectivities. —
(ZHANG, J.; DUETZ, W. A.; WITHOLT, B.; LI*, Z.; Chem. Commun. (Cambridge)
2004, 18, 2120-2121; Inst. Biotechnol., ETH Zuerich, CH-8093 Zuerich, Switz.;
Eng.) — M. Paetzel
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