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2005
Thiophene derivatives
R 0090
Synthesis of 2-Amino-3-heteroaroylthiophenes and Evaluation of Their Activity
Potential Allosteric Enhancers at the Human A1 Receptor. — The synthesis of a
11- 127 as
series of title compounds (III) by a known procedure is reported. The effect of substituents at positions 4 and 5 of the thiophene ring on enhancer activity and the ability of
the new substances to reduce the cAMP content in CHO cells expressing the human
adenosine A1 receptor are evaluated. — (BARALDI*, P. G.; PAVANI, M. G.;
SHRYOCK, J. C.; MOORMAN, A. R.; IANNOTTA, V.; BOREA, P. A.;
ROMAGNOLI, R.; Eur. J. Med. Chem. 39 (2004) 10, 855-865; Dip. Sci. Farm., Univ.
Ferrara, I-44100 Ferrara, Italy; Eng.) — H. Haber
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