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2005
Terpenes
U 0200
11- 189
Synthesis and Antileishmanial Profile of Some Novel Terpenyl Pyrimidines. —
α-Oxoketene dithioacetals (I) react with guanidine (II) in different alcohols under
reflux conditions to furnish novel terpenyl pyrimidine derivatives. The problematic
preparation of (III) using these conditions is circumvented by carrying out the reaction
in isopropyl alcohol at higher temperature in a steel bomb. Pyrimidine (IX) is prepared
from β-ionone (VI) via the ketoester (VIII). Compounds (III), (V), and (IX) display
promising in vivo antileishmanial activity. Interestingly, (IX) reveals 63% activity on
day 28, which probably is acting through immunostimulation. — (PANDEY, S.;
SURYAWANSHI*, S. N.; GUPTA, S.; SRIVASTAVA, V. M. L.; Eur. J. Med. Chem.
39 (2004) 11, 969-973; Div. Med. Chem., Cent. Drug Res. Inst., Lucknow 226 001,
India; Eng.) — H. Hoennerscheid
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