close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Triazine derivatives
R 0655
Easy Access to 3- or 5-Heteroarylamino-1,2,4-triazines by SNAr, SHN , and PalladiN-Heteroarylations. — By treatment of heteroaromatic amines with
12- 170 um-Catalyzed
two superbasic mixtures (TMP/tBuOM/BuLi, M: Na, K), the corresponding metal heteroaryl amides are formed. They react regioselectively with triazinyl thioether (II) to
afford SNAr products (III) and SHN products (IV). With the superbase derived from
tBuOK predominantly 5-amino-substituted products (IV) are obtained, except for
amine (IIh). In the presence of TMP/tBuONa/BuLi 3-substituted compounds (III) are
formed as major products, except for amine (IIb). Triazines (III) are also prepared by
Pd-catalyzed N-arylations in good yields. — (GARNIER, E.; AUDOUX, J.;
PASQUINET, E.; SUZENET, F.; POULLAIN, D.; LEBRET, B.; GUILLAUMET*, G.;
J. Org. Chem. 69 (2004) 23, 7809-7815; Inst. Chim. Org. Anal., CNRS, Fac. Sci.,
Univ. Orleans, F-45067 Orleans, Fr.; Eng.) — Klein
2005
Документ
Категория
Без категории
Просмотров
1
Размер файла
30 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа