close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Nucleic acids
U 0700
An Improved Method for Synthesizing Cyclic Bis(3'-5')diguanylic Acid
— Two major drawbacks of a previously reported synthesis of the bio12- 214 (c-di-GMP).
logically important title acid (XIII) are eliminated. The first one concerns the regioselective production of the key intermediate (IV) and utilizes the Furusawa method for
the 3',5'-di-O-protection of guanosine by the di-tert-butylsilanediyl group. The second
improvement is achieved by an easy and high-yielding preparation of (VI) which is
characterized by use of the dimethylformamidine group as protector for the NH2-function of the guanine base. These modifications result in an approximately ten-fold better
yield for the target compound. — (HYODO, M.; HAYAKAWA*, Y.; Bull. Chem.
Soc. Jpn. 77 (2004) 11, 2089-2093; Grad. Sch. Hum. Inf., Nagoya Univ., Chikusa,
Nagoya 464, Japan; Eng.) — H. Hoennerscheid
2005
Документ
Категория
Без категории
Просмотров
0
Размер файла
38 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа