close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Alcohols
Q 0230
13- 074
anti-Selective and Regioselective Aldol Addition of Ketones with Aldehydes
Using MgI2 as Promoter. — The coupling of symmetrical ketones with aromatic and
aliphatic aldehydes in the presence of stoichiometric amounts of MgI2 and piperidine
as base proceeds with high anti-aldol selectivitiy especially for propiophenone to
afford hydroxy ketones (III). In the case of unsymmetrical ketones, both piperidine and
iPr2NEt give the aldol products with the same ratio of regioselectivity. However, by use
of iPr2NEt the amount of MgI2 can be reduced and the reaction proceeds in a shorter
reaction time. The addition of aldehydes to unsymmetrical ketones occurs at the less
hindered α-side. — (WEI*, H.-X.; JASONI, R. L.; SHAO, H.; HU, J.; PARE, P. W.;
Tetrahedron 60 (2004) 51, 11829-11835; Dep. Chem. Biochem., Tex. Tech. Univ.,
Lubbock, TX 79409, USA; Eng.) — Klein
Документ
Категория
Без категории
Просмотров
0
Размер файла
32 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа