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2005
Pyrrole derivatives
R 0120
Syntheses, in vitro Antibacterial and Cytotoxic Activities of a Series of
Succinimides. — About 40 succinimides are synthesized, most of them
13- 119 3-Substituted
according to literature procedures. Within the series of fourteen aminomethyl succinimides only two of them display moderate antibacterial activity: compound (III) versus
P. aeruginosa and (V) versus E. faecalis. Twenty molecules with an ester sub-unit such
as (IV) exhibit moderate activity against Gram-positive bacteria. Compounds with the
lowest minimal inhibitory concentrations are also the most cytotoxic ones against green
monkey Vero cell line. — (ZENTZ*, F.; LE GUILLOU, R.; LABIA, R.; SIROT, D.;
LINARD, B.; VALLA, A.; Farmaco 59 (2004) 11, 879-886; Chim. Biol. Subst. Nat.,
CNRS, F-29000 Quimper, Fr.; Eng.) — H. Hoennerscheid
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