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2005
Alkaloids
U 0600
14- 197
Synthesis and Amine Transporter Affinities of Novel Phenyltropane Derivatives
as Potential Positron Emission Tomography (PET) Imaging Agents. — Starting
with cocaine compounds such as (I) are synthesized which have a high affinity for
SERT (Ki: 0.18, 0.24 and 0.30nM, respectively). For 18-F-labeled compounds, used for
PET imaging, corresponding tosylates as starting materials are also prepared. —
(PENG, X.; ZHANG, A.; KULA, N. S.; BALDESSARINI, R. J.; NEUMEYER*, J. L.;
Bioorg. Med. Chem. Lett. 14 (2004) 22, 5635-5639; Med. Chem. Lab., McLean
Hosp., Harvard Med. Sch., Belmont, MA 02478, USA; Eng.) — K. Schneider
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