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2005
Nucleic acids
U 0700
Synthesis of 5'-Substituted Fluoro-neplanocin A Analogues: Importance of a
Bonding Donor at 5'-Position for the Inhibitory Activity of S-Adenosyl14- 203 Hydrogen
homocysteine Hydrolase. — Starting with the optically active key intermediate (I),
derived from D-ribose, different analogues of the title compound such as (VI) and (VII)
are synthesized. The structure—activity relationships are discussed in detail and it is
found that (V) and (VI) are less cytotoxic than fluoro-neplanocin A in human colon
cancer cell lines (Co12) and human lung cancer cell lines (A549). — (MOON, H. R.;
LEE, H. J.; KIM, K. R.; LEE, K. M.; LEE, S. K.; KIM, H. O.; CHUN, M. W.; JEONG*,
L. S.; Bioorg. Med. Chem. Lett. 14 (2004) 22, 5641-5644; Lab. Med. Chem., Ewha
Womans Univ., Seoul 120-750, S. Korea; Eng.) — K. Schneider
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