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2005
Nucleic acids
U 0700
Covalent Analogues of DNA Base-Pairs and Triplets. Part 7. Synthesis and CytoActivity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides. —
14- 205 static
Bis(purinyl)acetylene and -diacetylene nucleosides such as (I), (II), and (III) are prepared by using the Sonogashira cross-coupling technique or by oxidative alkyne-dimerization reactions. The covalent dinucleosides (Ib), (Ic), and (III) as well as the mononucleoside (Ia) and base-pair (II) are tested for their inhibition of cell growth of four
cell cultures. Surprisingly, in general the more hydrophobic acyl-protected compounds
are more active than the hydrophilic free nucleosides. — (NAUS, P.; VOTRUBA, I.;
HOCEK*, M.; Collect. Czech. Chem. Commun. 69 (2004) 10, 1955-1970; Inst. Org.
Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic;
Eng.) — H. Hoennerscheid
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