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2005
Enzyme inhibiting activity
X 0220
Discovery and SAR of 2-Aminothiazole Inhibitors of Cyclin-Dependent Kinase
as a Potential Treatment for Alzheimer's Disease. — Starting from a
14- 225 5/p25
high-throughput screening hit a novel set of compounds is synthesized. The structure—activity relationship investigation shows an improvement in potency and selectivity by the emplacement of fused heteroaryl rings. — (HELAL*, C. J.; et al.;
Bioorg. Med. Chem. Lett. 14 (2004) 22, 5521-5525; Neurosci. Med. Chem., Pfizer
Global Res. Dev., Groton, CT 06340, USA; Eng.) — K. Schneider
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