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2005
Enzyme inhibiting activity
X 0220
Isoxazole Carboxylic Acids as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibi— Ongoing research leads to the identification of two novel very active com14- 226 tors.
pounds (I) as PTP1B inhibitors. Especially compound (Ia) also shows a good cellular
activity. On the basis of X-ray crystal structure of the protein in complex with the inhibitor the biological results are discussed. — (ZHAO*, H.; et al.; Bioorg. Med.
Chem. Lett. 14 (2004) 22, 5543-5546; Metab. Dis. Res., Abbott Lab., Abbott Park,
IL 60064, USA; Eng.) — K. Schneider
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