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2005
Polyphenylalkene derivatives
Q 0740
Stilbene-Based Inhibitors of Estrone Sulfatase with a Dual Mode of Action in HuBreast Cancer Cells. — A variety of sulfamoyloxy-substituted stilbenes such as
15- 083 man
(VII) and (VIII) with side chains that guarantee antiestrogenic activity are synthesized
and evaluated as inhibitors of estrone sulfatase. Compound (VIIc), the most potent derivatives, inhibits the growth of wild-type human MCF-7 cells with an IC50 value of 13
nM. — (WALTER, G.; LIEBL, R.; VON ANGERER, E.; Arch. Pharm. (Weinheim,
Ger.) 337 (2004) 12, 634-644; Inst. Pharm., Univ. Regensburg, D-93053 Regensburg,
Germany; Eng.) — R. Langenstrassen
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