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2005
Quinones
Q 0910
15- 088
Synthesis of the Naphthalene-Derived Inhibitors Against Cdc25A Dual-Specificity Protein Phosphatase and Their Biological Activity. — A variety of naphthalene and naphthoquinone derivatives are synthesized and evaluated for their in vitro
Cdc25A phosphatase-inhibitory activity. SAR studies indicate that the naphthoquinone
core with a methoxy substituent, instead of a methylamino group as in natural
pyranonaphthoquinones, is an important factor to show high activity of phosphatase inhibition. — (SHIMBASHI, A.; TSUCHIYA, A.; IMOTO, M.; NISHIYAMA*, S.;
Bioorg. Med. Chem. Lett. 15 (2005) 1, 61-65; Dep. Chem., Fac. Sci. Technol., Keio
Univ., Kohoku, Yokohama 223, Japan; Eng.) — R. Langenstrassen
2005
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