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2005
Fused pyridine derivatives
R 0450
Cobalt-Mediated Cyclotrimerization of Bis-alkynes and Cyanamides. —
(II) and (VIII) can undergo co-cyclotrimerization with bis-alkynes, such
15- 140 Cyanamides
as (I), in the presence of a CpCo(CO)2 catalyst under relatively mild conditions. This
process offers an approach to highly elaborated 2-aminopyridines, including amino-substituted pyridinophanes, e.g. (VII). Interestingly, unsymmetrical bis-alkynes
(Ic)—(Ie) give selectively one regioisomer. — (BONAGA, L. V. R.; ZHANG, H.-C.;
MARYANOFF*, B. E.; Chem. Commun. (Cambridge) 2004, 21, 2394-2395; Drug
Discovery, Johnson & Johnson Pharm. Res. Dev., Spring House, PA 19477, USA;
Eng.) — M. Paetzel
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